The Correlation Between Serum Anti-tissue Transglutaminase (Anti-tTG) Antibody Levels and Histological Severity of Celiac Disease in Adolescents and Adults: A Meta-Analysis.

Cureus · 2023 · PMC10814693 · PMID 38283435

Europe PMC DOI

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highly significantno p-value reported

Marsh 0 Levels of anti-tTG antibody in subjects with grade Marsh grade IIIb compared to Marsh grade 0 revealed a highly significant difference, which means that the observed difference is not due to chance (SMD 1.48; 95% CI: 0.99, 1.96).

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a clear trendno p-value reported

Our meta-analysis revealed a consistent, robust correlation between anti-tTG antibody levels and the histological severity of celiac disease, with a clear trend of increasing antibody levels corresponding to the severity of mucosal damage.

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