GDF15 Protects Insulin-Producing Beta Cells against Pro-Inflammatory Cytokines and Metabolic Stress via Increased Deamination of Intracellular Adenosine.

At palmitate + high-glucose conditions, there was a nonsignificant trend to increased inosine in GDF15-treated cells ( Figure 7 A).

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In the presence of palmitate + high glucose, imatinib tended to increase pro-GDF15, but this did not reach statistical significance.

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