Reanalysis of Trio Whole-Genome Sequencing Data Doubles the Yield in Autism Spectrum Disorder: De Novo Variants Present in Half.

Int J Mol Sci · 2024 · PMC10816071 · PMID 38256266

Europe PMC DOI

hedged sentences

0.0800

closest p · 1.6× alpha

0.1800

boldest claim

The sentences

a negative trendp = 0.08so close (0.05 < p ≤ 0.1)

Neither manifestation alone was statistically significant; although, there was a negative trend for PDV identification in subjects with tics ( p = 0.08).

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a possible trendp = 0.18not close (p > 0.1)

Cases with and without a PDV are not significantly more or less likely to have an affected first-degree relative with a substantial NDD; although, there is a possible trend (+PDV 13/34 (38%) with a first-degree relative affected, no PDV 3/16 (19%), p = 0.18, odds ratio 2.7, 95% CI 0.6–11).

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