<i>KCNQ1</i> p.D446E Variant as a Risk Allele for Arrhythmogenic Phenotypes: Electrophysiological Characterization Reveals a Complex Phenotype Affecting the Slow Delayed Rectifier Potassium Current (IKs) Voltage Dependence by Causing a Hyperpolarizing Shift and a Lack of Response to Protein Kinase A Activation.

Int J Mol Sci · 2024 · PMC10816087 · PMID 38256028

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0.0800

closest p · 1.6× alpha

0.0800

boldest claim

The sentences

did not reach statistical significancep = 0.08so close (0.05 < p ≤ 0.1)

While the voltage sensitivity of both IKs-446 D/E and IKs-446 E/E was higher than that of IKs-WT, the difference between the wildtype and heterozygous forms did not reach statistical significance ( p = 0.08).

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