Barely Significant
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Determinants of bleeding before and during immune tolerance in 222 boys with severe hemophilia A and inhibitors >5 BU.

Blood Adv · 2024 · PMC10820329 · PMID 38214949

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a nonsignificant trendno p-value reported
AJBR showed a nonsignificant trend of increased bleeding for those with the highest inhibitor titers.

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showed a trendno p-value reported
Findings for BPA prophylaxis showed no reduction in ABR or AJBR for rFVIIa prophylaxis (generally administered 3 times per week) during ITI but showed a trend toward ABR reduction (adjusted hazard ratio [aHR], 0.68) and a significant AJBR reduction (aHR, 0.37; 95% CI, 0.18-0.77) for aPCC prophylaxis, which was administered twice daily for majority of the patients.

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