Current Standards, Multidisciplinary Approaches, and Future Directions in the Management of Extrahepatic Cholangiocarcinoma.

Curr Treat Options Oncol · 2024 · PMC10824875 · PMID 38177560

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.1600

boldest claim

The sentences

a numerical trendp = 0.06so close (0.05 < p ≤ 0.1)

While there was a numerical trend towards improved PFS in the GemOx + cetuximab KRAS-wild type arm, this was not significant (mPFS 7.1 months [GemOx + cetuximab] vs 5.6 months [GemOx]; p = 0.06) [ 118 ].

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trending towards significancep = 0.16not close (p > 0.1)

Another review including 45 patients with eCCA ( n = 33 [adjuvant RT]; n = 12 [neoadjuvant CT]) found that 11 (91%) patients treated neoadjuvantly had R0 resections and numerically improved 5-year OS, trending towards significance (53% vs 23%; p = 0.16) compared to those who received adjuvant treatment [ 69 ].

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