Crosstalk between MicroRNAs and Oxidative Stress in Coeliac Disease.

However, in CeD-GFD blood, 8-OHdG levels showed a trend toward a statistically significant positive correlation with miR-200 ( r = 0.37, p = 0.07) and a negative correlation with miR-1226 ( r = −0.38, p = 0.07).

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Despite an evident trend towards higher levels for several miRNA in patients with CeD not on a GFD, probably due to small sample size and high biologic variability, no statistically significant difference in circulating levels among the evaluated miRNAs was demonstrated between groups ( Fig. 2 ).

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Our pilot study did not find any statistically significant differences in the levels of miRNAs and oxidative stress markers between the different groups evaluated, as well as no correlations between different miRNAs and 8-OHdG in all groups (except for a positive correlation with miR-200 and a negative correlation with miR-1226 in CeD-GFD as a trend toward significance).

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