Astaxanthin and meclizine extend lifespan in UM-HET3 male mice; fisetin, SG1002 (hydrogen sulfide donor), dimethyl fumarate, mycophenolic acid, and 4-phenylbutyrate do not significantly affect lifespan in either sex at the doses and schedules used.

Geroscience · 2024 · PMC10828146 · PMID 38041783

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

approached significancep = 0.06so close (0.05 < p ≤ 0.1)

The 90th percentile for PBA in females was reduced 6%, and this approached significance using the Wang–Allison test ( p = 0.06).

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highly significantno p-value reported

2 C), using in vivo mouse markers, found highly significant senescent cell reduction immediately, 2 weeks, and 4 weeks after feeding 500 ppm Fis.

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