Transcriptomics and biochemical evidence of trigonelline ameliorating learning and memory decline in the senescence-accelerated mouse prone 8 (SAMP8) model by suppressing proinflammatory cytokines and elevating neurotransmitter release.

Geroscience · 2024 · PMC10828270 · PMID 37721682

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did not reach statistical significanceno p-value reported

TG treatment could slightly increase the BDNF level in SAMP8 mice compared to the nontreated group (Δmean = 0.69, P = 0.27); however, this change did not reach statistical significance (Fig. 8 e).

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