Low circulating adropin concentrations predict increased risk of cognitive decline in community-dwelling older adults.

When adjusted for CCS and age at V1, years between first and final CCS measurement, years of education and medication, there was a strong trend for a difference between adropin tertiles ( F 2,446 = 2.931, P = 0.054; estimated marginal mean ± SE of ∆CCS for 1st, 2nd, and 3rd adropin tertiles, − 0.298 ± 0.059, − 0.253 ± 0.057, and − 0.104 ± 0.059, P = 0.065 between 1st and 3rd adropin tertiles).

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