Age-dependent genes in adipose stem and precursor cells affect regulation of fat cell differentiation and link aging to obesity via cellular and genetic interactions.

Genome Med · 2024 · PMC10829214 · PMID 38297378

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To limit multiple testing, we focused our analyses on the independent, regulatory variants with the strongest main effects on BMI, thus testing only the LD-clumped cis -regional variants of the age-DE SAT ASPC genes that showed nominally significant ( p <0.05) effects on BMI in the non-age-adjusted GWASs and landed within open chromatin regions of ASPCs[ 59 ].

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