Immune checkpoint inhibitors in cancer: the increased risk of atherosclerotic cardiovascular disease events and progression of coronary artery calcium.

However, after PSM, this difference did not reach statistical significance ( HR , 5.3 [95% CI , 0.6–45.5] vs. 5.1 [95% CI , 1.7–14.9]; P = 0.979) (Additional file 1 : Fig.

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In the multiple linear regression analysis, ICI therapy was a significant independent predictor of absolute volume progression, absolute score progression, relative volume progression, and relative score progression of CAC at 12 months across all models (absolute volume progression before PSM was marginally significant in model 2), both before and after PSM (Additional file 1 : Table S15, Table 4 ).

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