Pharmacologic inhibition of somatostatin receptor 2 to restore glucagon counterregulation in diabetes.

Front Pharmacol · 2023 · PMC10829877 · PMID 38298268

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failed to reach statistical significanceno p-value reported

In intact isolated islets from humans with T2D, glucagon secretion at 1 mmol/L glucose was lower (65% on average) than in non-diabetic human islets, though, a reciprocal trend towards elevated SST secretion failed to reach statistical significance as it did in Fh1βKO mouse islets ( Vergari et al., 2020 ).

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