Early resource scarcity causes cortical astrocyte enlargement and sex-specific changes in the orbitofrontal cortex transcriptome in adult rats.

When analyzed, a trend towards increased astrocytic surface area in male and female LBN subjects was observed, but this trend did not reach statistical significance, [F(1,12) = 4.20, p = .063] ( Fig. 2 D).

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First, an independent samples t -test was performed to see if there were significant differences between cortical layers in any of the morphological or PSD-95 related parameters, as previous literature demonstrated that there may be significant heterogeneity in morphometric properties of astrocytes between layers ( Langfelder and Horvath, 2008 ).

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