Pharmacogenomics of poor drug metabolism in greyhounds: Canine P450 oxidoreductase genetic variation, breed heterogeneity, and functional characterization.

As shown in Table 2 , although there was a trend for lower mean V max and CL int for the H3 and H4 variants compared to the reference H1 POR for both cytochrome c and NADPH kinetics, these differences did not reach statistical significance (P > 0.05, ANOVA).

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In silico analysis of POR amino acid variants Multiple sequence alignments of dog POR with homologs from other species showed that the 315 glutamate residue was largely conserved, indicating that this residue may be significant to the structure or function of the protein ( Fig 1A ).

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