Biological basis of extensive pleiotropy between blood traits and cancer risk.

A few nominally significant correlations were indicated, including lung cancer with white blood cell (leukocyte) counts (Additional file 1 : Table S13; and Additional file 2 : Fig.

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Our blood trait–cancer pleiotropy study identified nine variants in this set (Additional file 1 : Table S16), which represents a highly significant overlap if an equivalent genome coverage is assumed: identifying nine pleiotropic variants among sets of 85 variants against a background of approximately 5 million variants has a significance of p hypergeometric = 1 × 10 −19 .

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