Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging.

Front Aging · 2023 · PMC10844398 · PMID 38322248

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GO term analysis demonstrated a significant upregulation of DNA damage repair pathways in the D/KO enhanced reprogramming group including DNA repair, homologous recombination (HR), non-homologous end joining (NHEJ), base excision repair (BER), mismatch repair (MMR), nucleotide excision repair (NER), and alternative end joining (AltEJ), while interstrand crosslink repair (ICR) showed a trend towards upregulation.

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