There was a trend toward increased IgG titers in groups that received both IM and oral vaccines compared to the IM-only positive controls, but these differences did not reach statistical significance.
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Multimodal vaccination targeting the receptor binding domains of <i>Clostridioides difficile</i> toxins A and B with an attenuated <i>Salmonella</i> Typhimurium vector (YS1646) protects mice from lethal challenge.
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