On the other hand, the L35P and G449V mutant iPSC-CMs, which had milder defects in nuclear shape and size, showed no increase in nuclear-envelope rupture or only a trend towards increased nuclear-envelope rupture (G449V) that did not reach statistical significance ( p > 0.3 vs. healthy controls).
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Nuclear damage in <i>LMNA</i> mutant iPSC-derived cardiomyocytes is associated with impaired lamin localization to the nuclear envelope.
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