Calcium-binding protein 7 expressed in muscle negatively regulates age-related degeneration of neuromuscular junctions in mice.

In addition, Cabp7 cKO mice showed significant reductions in the areas of AChR clusters and presynaptic motor nerve terminals at 6, 12, and 24, but not 3 months of age, and in the cover ratio of presynaptic motor nerve terminals to postsynaptic AChR clusters at NMJs at 12 months of age, but not at other ages, while a nearly significant difference was shown at 24 months of age (p = 0.071) ( Figures 3 E–3G).

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