Noncanonical interaction with microtubules via the N-terminal nonmotor domain is critical for the functions of a bidirectional kinesin.

Last, cells expressing the Cin8Δ1–69 variant (which was unable to support viability in cin8 Δ kip1 Δ cells) also exhibited an increased percentage of mislocalized motors compared to cells expressing wt Cin8, but this difference did not reach statistical significance ( Fig. 2B ).

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