Combined Immunotherapy Improves Outcome for Replication-Repair-Deficient (RRD) High-Grade Glioma Failing Anti-PD-1 Monotherapy: A Report from the International RRD Consortium.

Cancer Discov · 2024 · PMC10850948 · PMID 37823831

Europe PMC DOI

hedged sentence

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

did not reach statistical significanceP = 0.06so close (0.05 < p ≤ 0.1)

A similar impact of reirradiation was observed for combined anti–PD-1 and trametinib, which likely did not reach statistical significance because of small numbers ( P = 0.06; Supplementary Fig.

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