Multi-endpoint analysis of cadmium chloride-induced genotoxicity shows role for reactive oxygen species and p53 activation in DNA damage induction, cell cycle irregularities, and cell size aberrations.

After a 4 h treatment with CdCl 2 , an increase was seen in the expression of p21 with fold changes of 1.3- and 1.5-fold, however, these did not reach statistical significance.

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A highly significant response was seen with the positive control, hydrogen peroxide.

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