Image-guided metabolomics and transcriptomics reveal tumour heterogeneity in luminal A and B human breast cancer beyond glucose tracer uptake.

Their expression in the peripheral tumour of LumA also showed an increase, although it did not reach statistical significance threshold (Figure 4D ). 3.6 Metabolic differences between tumour centre and periphery in different tumour subtypes The oPLS‐DA score plot shows that the metabolic phenotype of LumA or LumB tumours is parallel in the centre and periphery (Figures 5A and B ).

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