Lacking P2X7-receptors protects substantia nigra dopaminergic neurons and hippocampal-related cognitive performance from the deleterious effects of high-fat diet exposure in adult male mice.

In P2X7 KO mice, AKT signal did not vary after HFD, while WT mice showed a trend to a reduction in the pAKT/AKT ratio ( Figure 6A ); FOXO3, a transcription factor involved in cell survival, did not show any modification ( Figure 6B ).

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