A Randomized Controlled Trial to Evaluate the Impact of a Novel Probiotic and Nutraceutical Supplement on Pruritic Dermatitis and the Gut Microbiota in Privately Owned Dogs.

There was a clear trend of an increase in all six supplemented probiotics in the PNB group but not the PBO, even though not all of them reached statistical significance with differential abundance analysis ( Figure S14 ).

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PNB supplementation led to significant increases in three supplemented probiotic species; however, there was an overall trend of an increase in all six probiotics included in the formulation.

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On the other hand, the increase of Pielou’s evenness ( p = 0.058) and Shannon H ( p = 0.062) from baseline to week 10 were borderline significant in the PNB group.

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