Involvement of Cyclooxygenase-2 in Establishing an Immunosuppressive Microenvironment in Tumorspheres Derived from TMZ-Resistant Glioblastoma Cell Lines and Primary Cultures.

As observed for OPN expression ( Figure 6 ), also for CD44 levels, the primary cultures showed a trend similar to cell lines since TMZ induced an increase in CD44 levels, and the drug combination lowered the CD44 expression to the CNTR levels in both primary cultures ( Figure 7 C,D). 3.5.

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