Defining the Role of the miR-145-KLF4-αSMA Axis in Mitral Valvular Interstitial Cell Activation in Myxomatous Mitral Valve Prolapse Using the Canine Model.

We further investigated the KLF4 protein expression pattern of VICs harvested directly from canine valves and found that mean KLF4 protein expression was reduced in VICs from MVP-affected valves, although it did not reach statistical significance ( p = 0.137) ( Figure 1 c).

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