The WMI Rat of Premature Cognitive Aging Presents Intrinsic Vulnerability to Oxidative Stress in Primary Neurons and Astrocytes Compared to Its Nearly Isogenic WLI Control.

In contrast, WMI hippocampal neurons, but not WLI, showed a trend of greater expression of the antioxidant Cat compared to cortical astrocytes, and a significantly decreased expression after treatment with H 2 O 2 (cell type, F[1,16] = 3.65, p = 0.074; H 2 O 2 , F[1,16] = 14.26, p < 0.01; Figure 2 C).

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