Potential of acetaminophen on the sublingual microcirculation and peripheral tissue perfusion of febrile septic patients: prospective observational study.

Although a comparison between septic and septic shock patients showed an interesting trend, the unequal sample size of the two groups, the restrained numbers of septic shock patients included and the strong variability of the sample at baseline, limit excessively the validity of those results and data on the different response between patients with sepsis and patients with septic shock need to be interpreted carefully, reproduced and eventually confirmed with randomized trial to avoid overinterpretation.

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Total vessel density of small and total vessels (TVDs, TVDt), De Backer score showed a trend towards an increase that was not statistically significant at the Friedman test for repeated measures (Fig. 1 , Additional file 2 ).

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