Monocyte-derived alveolar macrophages are key drivers of smoke-induced lung inflammation and tissue remodeling.

Front Immunol · 2024 · PMC10859862 · PMID 38348034

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a strong trendp = 0.08so close (0.05 < p ≤ 0.1)

Significantly decreased levels of the MoAM associated chemokines CCL2 and CCL7 (21% and 69%, respectively) and a strong trend towards decreased total BALF macrophage counts (30% decrease on average, p = 0.08) in treated animals further corroborates the anti-inflammatory effect of the IRAK4 inhibitor ( Figures 8B, C ).

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