Oral Probiotic Supplementation in Pregnancy to Reduce Group B Streptococcus Colonisation (OPSiP trial): study protocol for a double-blind parallel group randomised placebo trial.

Sharpe et al ’s study with 113 participants with unknown status, although not statistically significant, showed a trend towards efficacy with a 15.8% GBS positive rate following 12 weeks of intervention from 23 to 25 weeks’ gestation (two capsules daily) in the probiotic arm versus 21.43% in the placebo arm (p=0.48). 49 Two other trials failed to find a difference in GBS colonisation rates 50 51 ; however, each only used one capsule a day.

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