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Liquid crystalline inverted lipid phases encapsulating siRNA enhance lipid nanoparticle mediated transfection.

Nat Commun · 2024 · PMC10861598 · PMID 38347001

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15 ) Pre-programmed inverse hexagonal structures remain stable upon interaction with LUVs After establishing a clear trend in transfection efficiency when comparing LNPs with defined lipid structures, we sought to gain more mechanistic insights into the LNP-membrane interaction.

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