Single-Cell Transcriptional Profiling and Gene Regulatory Network Modeling in Tg2576 Mice Reveal Gender-Dependent Molecular Features Preceding Alzheimer-Like Pathologies.

Considering both genders together, we observe a nominally significant increased expression of App / APP in TG mice compared to WT controls in neurons ( p value = 1.72E-05, adjusted p value = 0.33) using a Poisson generalized linear model [ 17 ].

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