Inherited polygenic effects on common hematological traits influence clonal selection on JAK2<sup>V617F</sup> and the development of myeloproliferative neoplasms.

Germline predisposition to high MONO and PCT values was also positively associated with large JAK2 V617F clones at modest significance ( P = 0.033 and 0.0022, FDR-adjusted P = 0.31 and 0.064; Fig. 1a ).

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