“modest significance”

Association testing on all HLA alleles in a combined group of persistent and extended oligoarthritis JIA ILAR subtypes revealed that position 11 of HLA‐DRB1 was again the strongest signal, but with a more modest significance ( P = 5.1 × 10 −14 ).

Statistical power drops off rapidly as the interaction odds ratio goes from 1.50–1.25; even at a modest significance level of P < 10 −7 , we did not have power to detect an interaction with an odds ratio of 1.25 for any condition ( Table S7 ).

The correlation between the fold changes of PCNA and the Z scores of V$NFKAPPAB65_01 showed a modest significance (r 2 = 0.0616; p < 0.0049; q < 0.04) (Figure 2D ).

Effects with p -values between 0.01 and 0.05 were considered as offering modest significance and effects with p < 0.01 as offering stronger evidence of a difference.

T 2peak showed modest significance for the interaction between soil extracts and drying-rewetting cycles ( p = 0.011, ɳp 2 = 0.14), and for the three-way interaction among soil extracts, polymer type, and drying-rewetting cycles ( p = 0.018, ɳp 2 = 0.14).

84 , 85 Downregulated proteins included C2, C3, C4A, C4B, C5, C6, and C7, with C5, C6, and CFB showing modest significance (adjusted P s = 0.050–0.051) and CFI, a key regulator, showing the most significant reduction (adjusted P = 0.013).

2 D) also increases over time, where again the change is dramatic in the PANC1 + MRC5 AOCs (increase in mean size of about 4 times in 24 h, p < 0.01) and less so in the PANC1 + PSC AOCs (factor of 1.8 increase with modest significance of p = 0.02 over the same time period).

Similarly, the difference between siVDAC3 cells expressing GFP and GFP-VDAC1 was of only modest significance ( p < 0.025) ( Figure 8 A).

Germline predisposition to high MONO and PCT values was also positively associated with large JAK2 V617F clones at modest significance ( P = 0.033 and 0.0022, FDR-adjusted P = 0.31 and 0.064; Fig. 1a ).

With the exception of integration nearby CpG islands, which likely attained a modest significance due to our large datasets ( P = 0.037), the Hdgfrp2 KO did not significantly impact the frequencies at which HIV-1 targets mouse genomic features ( Table 1 ; Figures 5 and 6 ).

Only FRRS1L protein showed a modest significance and only in the first set (p=0.040, when not adjusted for multiple comparison).

Notably, the contrast of visual faces over auditory false belief and false photo stories reached only modest significance in the fSTS ( p = 0.04 and p = 0.005, respectively), perhaps reflecting amodal processing and/or interference in the STS produced by the required mentalization during these stories.

Last but not least, low expression levels of NPR3 exhibited modest significance for longer OS ( p = 0.043) ( Figure S22F ).

The comparison between ES and adult brain tissue indicated that miR-124 showed modest significance as overrepresented in brain ( P = 0.044), suggesting that the miRNA may be more important in the mature brain tissue than neuronal-differentiating ES cells.

However, a logistic regression analysis revealed that sex exhibited modest significance as a predictor factor ( p = 0.0472).

8, p = 2.4 × 10 − 8 ) and modest significance in developmental disorders (Chap. 20) ( p = 0.049).

This may account for the modest significance level and effect size ( p = 0.049, V = 0.23) observed between study decade and the use of suicidal ideation as an exclusion criterion; thus, these findings should be interpreted with caution.

Spearman rank correlation of the POTS scores and numbers of down-regulated off-targets observed for each siRNA indicated a positive correlation of modest significance ( Figure 5 D, dotted line, P = 0.05).

Although the rescue patterns in liver models were less pronounced than those seen in prostate and breast cells, Eb still showed modest protective effects, with modest significance emerging in specific comparisons ( p < 0.05).

A modest significance ( p = 0.05) was observed in the association between routine childhood immunization completion and single facility use throughout the immunization period (78.5%) compared to multiple the facility use categories.

Subgroup 3 (subjects exposed to FQ for 91–180 days before the index date) showed modest significance in adjusted odds ratio (1.42, P = 0.06, 95% CI 0.99–2.05).

The incidence of HIV infection was the highest among blood group A secretors and when compared to blood group O, this difference was significant (p = 0.028; OR, 1.556; 95% CI, 1.061–2.280), blood group B, of modest significance (p = 0.066; OR, 1.625; 95% CI, 0.944–2.799) and blood group AB, not significant (p = 0.355; OR, 1.5; 95% CI, 0.573–3.930) as shown in Table 4 .

Among them, Cluster-3 is of our special interest because ∼95% of patients in this group have mutated TP53 gene and its survival profile is poorer than that of the other clusters with a modest significance ( P = 0.07, logRank test).

Correlations between RF-predicted and real patient survival on held-out samples were in the range of 0.12 to 0.35 for six TCGA cohorts (Additional file 1 : Figure S9) with corresponding modest significance ( p <0.1) for acute myeloid leukemia (AML) and skin cutaneous melanoma (SKCM), and stronger significance ( p <0.013) for head and neck squamous cell carcinoma (HNSC), glioblastoma multiforme (GBM), lung adenocarcinoma (LUAD), and ovarian serous cystadenocarcinoma (OV).

A second measure of demand generation—exposure to family planning messages in the media at the community level—did not have the expected relationship in the multivariate model, only reaching modest significance (p < .10) in Burkina Faso, Uganda, and Kenya with regard to short-acting contraceptive use and Ghana with regard to long-acting method use.