TYK2 signaling promotes the development of autoreactive CD8<sup>+</sup> cytotoxic T lymphocytes and type 1 diabetes.

The expressions of ISGs ( Gbp3 , Bst2 , and Isg20 ), chemokines ( Cxcl9 and Cxcl10 ), a type I IFN receptor ( Ifnar2 ), and type I IFNs ( Ifnb , Ifna1 ) were slightly lower in β-cells from 11w Tyk2 −/− mice compared with 11w Tyk2 +/+ mice, although they did not reach statistical significance (Fig. 2d, e ).

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