The use of synaptic biomarkers in cerebrospinal fluid to differentiate behavioral variant of frontotemporal dementia from primary psychiatric disorders and Alzheimer's disease.

Alzheimers Res Ther · 2024 · PMC10865562 · PMID 38355535

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A previous study, using [ 18 F]UCBH-PET as a tracer for synaptic vesicle protein 2A (SV2A) which reflects synaptic density, showed a trend for synaptic loss in the temporal social brain in bvFTD, highlighting the clinical relevance of synaptopathy in disease pathophysiology of FTD [ 14 ].

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