Evolutionary conservation of putative suicidality-related risk genes that produce diminished motivation corrected by clozapine, lithium and antidepressants.

All of the mutants showed a highly significant response to cyproheptadine and restoration of wild-type activity.

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Genes that affected locomotion and development appeared to be over-represented, whereas the aldicarb (cholinesterase inhibitor) phenotype (15 genes) showed a trend toward enrichment.

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