Meaningful digital biomarkers derived from wearable sensors to predict daily fatigue in multiple sclerosis patients and healthy controls.

Figure 1 shows a clear trend between average VAS fatigue ratings and FSMC scores.

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While increases in variability of sympathetic activity while awake are calculated to increase state fatigue for MS patients with a functional ANS, a positive trend in sympathetic activity is linked with decreased state fatigue for MS patients with a dysfunctional ANS.

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