Osmolar Modulation Drives Reversible Cell Cycle Exit and Human Pluripotent Cell Differentiation via NF-κВ and WNT Signaling.

Furthermore, the transcriptional cell cycle signature of Osm G and Osm M ‐treated hiPSC‐HLCs showed a trend resembling that of cultured PHH.

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Interestingly, Gene Ontology (GO) term enrichment analysis at 36 h revealed that among the downregulated genes, cell cycle‐related terms were highly significant enriched (Figure S1D and Table S5 , Supporting Information), indicated by the downregulation of the pro‐proliferative ( CDK1 , CDK2, E2F1 , and MYC ) and proliferative markers ( MKI67 , PCNA ).

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