Reduced progranulin increases tau and α-synuclein inclusions and alters mouse tauopathy phenotypes via glucocerebrosidase.

Indeed, high-magnification confocal image analysis revealed an increase in AT8-positive tau inclusions in the CA2 + CA3 and amygdala regions of PS19 Grn +/− and PS19 Grn −/− mice, although the increase did not reach statistical significance in PS19 Grn +/− mice (Fig. 3g, h ).

also in 111,027 other papers