showed a trendp-value = 0.012
Furthermore, the percentage of cells assigned to each cell type in each sample was not significantly different between treatment groups ( Supplementary Table 3 ), except for excitatory cells subtype F showed a trend towards a higher percentage in CIE-treated mice (nominal p-value = 0.012) and OPCs that showed a trend towards a lower percentage in CIE-treated mice compared to controls (nominal p-value<0.05, Supplementary Fig. 2a , b ).