Domain-inlaid Nme2Cas9 adenine base editors with improved activity and targeting scope.

Nat Commun · 2024 · PMC10874451 · PMID 38368418

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0.2600

closest p · 5.2× alpha

0.2600

boldest claim

The sentences

did not reach statistical significancep = 0.26not close (p > 0.1)

Within the striatum the trend continued, with both Nme2-ABE8e-i1 and Nme2-ABE-i1 V106W exhibiting improved editing activities (~37% and ~34% at A6 of Rosa26 ), compared to Nme2-ABE-nt (~25%), albeit this improvement did not reach statistical significance (p = 0.26 and 0.5, for Nme2-ABE8e-i1 and Nme2-ABE-i1 V106W respectively) (Fig. 5b ).

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