Prolonged versus intermittent β-lactam infusion in sepsis: a systematic review and meta-analysis of randomized controlled trials.

Ann Intensive Care · 2024 · PMC10874917 · PMID 38368588

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

showed a trendP = 0.06so close (0.05 < p ≤ 0.1)

In Roberts’ study, critically ill patients with an APACHE II score over 22 showed a trend of reduced hospital mortality with continuous infusion (RR, 0.74; 95% CI 0.53–1.01; P = 0.06).

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a favorable trendno p-value reported

Concerning APACHE II scores, our results suggest a favorable trend in mortality reduction with prolonged infusion in critically ill patients, irrespective of an APACHE II score above or below 20, differing from Roberts’ meta-analysis findings [ 38 ].

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