Phenotypic and genome-wide studies on dicarbonyls: major associations to glomerular filtration rate and gamma-glutamyltransferase activity.

Findings Mutual correlations of dicarbonyls were highly significant, being stronger between MG and GO (ρ = 0.6) than between 3-DG and MG or GO (ρ = 0.4).

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Furthermore, we observed a significant association of ferritin to GO and, with borderline significance, to MG.

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Serum 3-DG concentrations correlated with smoking which was highly significant in the KORA sample, with the same direction nominally significant in BiDirect, and significant in the meta-analysis.

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