TOP1 and R-loops facilitate transcriptional DSBs at hypertranscribed cancer driver genes.

iScience · 2024 · PMC10875566 · PMID 38375218

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a clear trendno p-value reported

Upon further analysis based on expression levels, a clear trend emerged: highly expressed driver genes exhibited decreased DSBs in response to these manipulations, while lowly expressed driver genes did not show a similar pattern ( Figures 7 H and 7I).

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