CRISPR/Cas9 deletion of MIR155HG in human T cells reduces incidence and severity of acute GVHD in a xenogeneic model.

Furthermore, our data show a significant increase in expression of exhaustion markers LAG3 and Tim-3 ( P < .01) whereas increase in programmed cell death protein 1 (PD1) expression did not reach statistical significance in MIR155HG Δexon3 CD4 T cells compared with NT T cells ( Figure 3 F).

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