Fat-to-blood recirculation of partially dysfunctional PD-1⁺CD4 Tconv cells is associated with dysglycemia in human obesity.

Notably, the VAT of obese patients showed a trend of enrichment in CD4 Tconv public clonotypes compared to LC, regardless of PD-1 expression or diabetes status ( Figures 3 C, 3D, and S9 C).

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