The association of tadalafil exposure with lower rates of major adverse cardiovascular events and mortality in a general population of men with erectile dysfunction.

Of note the adjusted HR for these two subgroups still favored tadalafil (HR of 0.77 for MACE in the diabetic subgroup and 0.66 in the coronary artery subgroup comparing exposure to nonexposure) and were of similar magnitude as those observed in the overall cohort analysis in Objective 1; but these HR did not reach statistical significance with wider CIs, likely due to limited statistical power stemming from low event rates and smaller sample sizes.

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